Living with a rare disease often means working with more than one healthcare provider. For individuals and families affected by Generalized Arterial Calcification of Infancy (GACI), ARHR2, ENPP1 Deficiency, ABCC6 Deficiency, and related conditions, care can involve several medical specialties because these conditions may affect different parts of the body throughout a person’s life. GACI […]
The start of a new school year brings new teachers, schedules, activities and routines. For families affected by Generalized Arterial Calcification of Infancy (GACI), Autosomal Recessive Hypophosphatemic Rickets Type 2 (ARHR2), ENPP1 Deficiency, ABCC6 Deficiency and related rare conditions, it can also mean making sure a child’s medical and accessibility needs are understood before the […]
On August 7, 2026, families, friends, and supporters around the world will walk 3 km together for one powerful reason: to support the Brighter Hope Foundation community. The Worldwide Walk is more than just a virtual event—it’s a celebration of strength, connection, and hope for families affected by Generalized Arterial Calcification of Infancy (GACI) and […]
For years, GACI Global has been a trusted source of support, education, and advocacy for families affected by Generalized Arterial Calcification of Infancy (GACI), ARHR2, ENPP1 Deficiency, and ABCC6 Deficiency. Today, the organization is proud to announce a new chapter: GACI Global has officially rebranded as Brighter Hope Foundation. While the name has changed, the […]
Chronic pain and fatigue can be a major part of life for people living with GACI, ARHR2, ENPP1 Deficiency, ABCC6 Deficiency, and related conditions. These symptoms may be linked to calcification, complications affecting soft-tissues, bones and joints, mobility challenges, and the long-term burden of managing a progressive rare disease. While each person’s experience is different, […]
Autosomal Recessive Hypophosphatemic Rickets Type 2 (ARHR2) is a rare genetic disorder that affects how the body regulates phosphate, a mineral essential for building strong bones and teeth. ARHR2 is associated with mutations in the ENPP1 gene, the same gene involved in Generalized Arterial Calcification of Infancy (GACI). While GACI often presents during infancy with […]
Living with GACI (Generalized Arterial Calcification of Infancy) means navigating a rare and complex genetic condition that affects the body in profound ways. GACI is characterized by abnormal calcification in the arteries, which can lead to serious cardiovascular complications early in life. While the diagnosis can feel overwhelming, families today have access to growing medical […]
Living with ABCC6 Deficiency can involve a wide range of experiences, from serious medical challenges in infancy to slowly developing symptoms later in life. This rare genetic condition affects the body’s ability to regulate mineralization, increasing the risk of calcium buildup in arteries and soft tissues. Because symptoms can vary significantly and evolve over time, […]
Living with ENPP1 Deficiency presents a unique set of challenges that affect the body in complex and often life-altering ways. Because this rare genetic condition can lead to vascular calcification, bone abnormalities, and chronic pain, individuals and families may face uncertainty and fear, especially around diagnosis and long-term management. Yet with early intervention, continued monitoring, […]
