Connect. Educate. Hope.
Brighter Hope Foundation connects,
educates, and gives hope to families
affected by Generalized Arterial
Calcification of Infancy and ARHR2.
Mission Statement
Brighter Hope Foundation is a nonprofit organization whose mission is to connect families affected by Generalized Arterial Calcification of Infancy or Hypophosphatemic Rickets caused by ENPP1 Deficiency or ABCC6 Deficiency to each other and to the medical community.
What is GACI?
GACI stands for Generalized Arterial Calcification of Infancy and is pronounced GACKEE. GACI Type 1 is caused by mutations in both copies of the ENPP1 gene and is part of the disease spectrum of ENPP1 Deficiency. GACI Type 2 is caused by mutations in both copies of the ABCC6 gene and is part of the disease spectrum of ABCC6 Deficiency.
What is ARHR2?
ARHR2 stands for Autosomal Recessive Hypophosphatemic Rickets Type 2. All bones in the body can be affected by rickets. Patients who survive GACI Type 1 usually develop ARHR2. ARHR2 is caused by mutations in the ENPP1 gene and is part of the disease spectrum called ENPP1 Deficiency.
GACI Statistics
GACI affects males and females equally and occurs in populations all across the world. GACI manifests itself differently even within families with the same genetic cause of the disease. No two persons with GACI will have identical medical characteristics.
GACI is estimated to occur in approximately
1 out of every 64,000 pregnancies.
GACI was first described in medical literature in 1899.
Survival rates vary greatly, but are estimated around 50%.
Want to help? Support Brighter Hope Foundation with your donation today.
Brighter Hope Foundation is a 501c3 nonprofit and your charitable donation to Brighter Hope Foundation is tax-deductible.
Patient Stories
Every family’s journey with GACI and/or ARHR2 is unique. The road can be exhausting, challenging, heartbreaking, hopeful, and inspiring. Read on to discover some real life patient stories as told in their own words.
Receive Our Newsletter
